Reduction of anthralin inflammation by potassium hydroxide and Teepol.

Abstract

Application of 1% potassium hydroxide (KOH) reduced subsequent development of anthralin inflammation without loss of its therapeutic effect on psoriasis. Teepol had a similar but smaller effect on subsequent development of inflammation. The action of KOH appears to have resulted from enhanced oxidation of anthralin to inactive products and the action of Teepol to have increased anthralin solubility and removal. The effect of KOH and Teepol decreased with time after anthralin application and both were ineffective by 24 h, indicating that anthralin persists on the skin in an active form for up to 24 h after a single application. The reduction of anthralin inflammation without loss of therapeutic effect is potentially useful in short contact anthralin therapy.

• Authors: C M Lawrence, S Shuster, M Collins, J M Bruce
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 116 Issue 2 Pg. 171-7 (Feb 1987) ISSN: 0007-0963 [Print] England
• PMID: 3828212 (Publication Type: Journal Article)

Chemical References

• Fatty Alcohols
• Hydroxides
• Potassium Compounds
• teepol 610
• Potassium
• Anthralin
• potassium hydroxide

Topics

• Adolescent
• Adult
• Aged
• Anthralin (adverse effects, antagonists & inhibitors)
• Dermatitis (chemically induced)
• Fatty Alcohols (therapeutic use)
• Female
• Humans
• Hydroxides (therapeutic use)
• Male
• Middle Aged
• Potassium (therapeutic use)
• Potassium Compounds
• Psoriasis (drug therapy)