13-cis-retinal stimulates proliferation and induces intranuclear protein accumulation in the human mammary tumor cells MCF-7.

Abstract

The human mammary tumor cells MCF-7 show enhanced proliferation when treated with low doses (10(-8)-10(-7) M) of 13-cis Retinal (a vitamin A derivative). These results are independent of the growth medium used. We describe a novel effect of 13-cis Retinal: the increased synthesis and accumulation of nuclear proteins in chronically treated cells. The cytoplasmic proteins and proteins released to the culture medium are transiently and oppositly modified. Moreover, chronic treated cells have growth advantages over the untreated counterparts in a clonogenic soft agar assay.

• Authors: M Resnicoff, E E Medrano
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 143 Issue 1 Pg. 309-15 (Feb 27 1987) ISSN: 0006-291X [Print] United States
• PMID: 3827923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neoplasm Proteins
• Nucleoproteins
• Retinoids
• Retinaldehyde

Topics

• Breast Neoplasms (pathology)
• Cell Division (drug effects)
• Cell Line
• Cell Nucleus (drug effects, metabolism)
• Female
• Humans
• Kinetics
• Neoplasm Proteins (biosynthesis)
• Nucleoproteins (biosynthesis)
• Retinaldehyde (pharmacology)
• Retinoids (pharmacology)