[Electrophysiologic effects of diprafenone in supraventricular and ventricular tachycardia].

Abstract

The electrophysiologic effects of diprafenone were evaluated in 31 patients (9 X AV nodal reentrant tachycardia, 9 X Wolff-Parkinson-White syndrome, 4 X paroxysmal atrial fibrillation, 10 X recurrent ventricular tachycardia). Electrophysiologic studies were performed before and after intravenous infusion of 1.5 mg/kg body weight diprafenone in a period of 10 minutes. Diprafenone prolonged the mean RR interval during sinus rhythm from 690 +/- 109 ms to 789 +/- 93 ms and the maximal sinus node recovery time from 1081 +/- 216 ms to 1300 +/- 398 ms (p less than 0.001). The effective refractory period of the right atrium increased from 195 +/- 22 ms to 210 +/- 28 ms (p less than 0.01) and of the right ventricle from 220 +/- 20 ms to 235 +/- 20 ms (p less than 0.001). Diprafenone produced a prolongation of the antegrade effective refractory period of the AV node from 260 +/- 35 ms to 294 +/- 39 ms (p less than 0.01) and of the retrograde effective refractory period from 265 +/- 76 ms to 400 +/- 130 ms (p less than 0.001). The effective refractory periods of the Kent bundle increased: antegrade from 299 +/- 45 ms to 413 +/- 133 ms, retrograde from 252 +/- 33 ms to 286 +/- 169 ms (p less than 0.05). Suppression of inducibility was observed in 12 of 17 patients with supraventricular reentrant tachycardia, in 5 of 8 patients with atrial fibrillation and in 7 of 10 patients with recurrent ventricular tachycardia. The rate of supraventricular tachycardias decreased under the influence of the substance.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: M Manz, J Beermann, U Gerckens, B Lüderitz
• Journal: Zeitschrift fur Kardiologie (Z Kardiol) Vol. 75 Issue 12 Pg. 757-63 (Dec 1986) ISSN: 0300-5860 [Print] Germany
• Vernacular Title: Elektrophysiologische Wirkungen von Diprafenon bei supraventrikulärer und ventrikulärer Tachykardie.
• PMID: 3825226 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Arrhythmia Agents
• diprafenone
• Propafenone

Topics

• Anti-Arrhythmia Agents (therapeutic use)
• Atrial Fibrillation (drug therapy)
• Bundle of His (drug effects)
• Cardiomyopathy, Dilated (complications)
• Coronary Disease (complications)
• Electrocardiography
• Female
• Heart Ventricles (drug effects)
• Humans
• Male
• Middle Aged
• Propafenone (analogs & derivatives, therapeutic use)
• Tachycardia (drug therapy)
• Tachycardia, Atrioventricular Nodal Reentry (drug therapy)
• Tachycardia, Supraventricular (drug therapy)
• Wolff-Parkinson-White Syndrome (drug therapy)