[Peripheral hemodynamics and metabolic parameters influenced by amrinone at rest and following handgrip stress].

Abstract

Peripheral hemodynamics and metabolic parameters were studied in 12 healthy volunteers (mean = 24.6 years) and in 12 patients with coronary artery disease (mean = 51.1 years) at rest and after isometric handgrip exercise both before and after application of amrinone (1.5 mg/kg body weight i.v.). Amrinone produced a significant decrease in diastolic blood pressure during handgrip in patients and in volunteers by 10%. Heart rate increased by 4 to 8%. After application of amrinone there was a pronounced increase in forearm blood flow at rest by 50% and after handgrip by 30%. Amrinone is an effective vasodilator without altering systolic and mean arterial blood pressure or heart rate strongly. Amrinone did not influence metabolic parameters.

• Authors: P Peters, F Saborowski, R Griebenow
• Journal: Zeitschrift fur Kardiologie (Z Kardiol) Vol. 75 Issue 12 Pg. 751-6 (Dec 1986) ISSN: 0300-5860 [Print] Germany
• Vernacular Title: Periphere Hämodynamik und metabolische Parameter unter dem Einfluss von Amrinon in Ruhe und nach Handgrip-Belastung.
• PMID: 3825225 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amrinone
• Norepinephrine
• Epinephrine

Topics

• Adolescent
• Adult
• Amrinone (therapeutic use)
• Blood Pressure (drug effects)
• Coronary Disease (blood, drug therapy)
• Energy Metabolism (drug effects)
• Epinephrine (blood)
• Exercise Test
• Forearm (blood supply)
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Humans
• Middle Aged
• Norepinephrine (blood)
• Regional Blood Flow (drug effects)