Endrin is carcinogenic for rats, and most likely also for mice and dogs.
Endrin caused significant incidences of
malignant neoplasms at all sites. In one study, female rats were susceptible to the development of
neoplasms of the endocrine organs, particularly
carcinomas of the adrenal and pituitary glands as well as
neoplasms of the reproductive system. In other studies, female rats tended to have
carcinomas of the endocrine system, the mammary gland and reproductive system, and male and female rats
lymphomas. Rats developed unusual
malignant neoplasms, such as Kupffer cell
sarcomas of the liver and
sarcomas of the mammary gland, uterus, and stomach. There also were toxic changes, particularly in male rats, ingesting
endrin. These lesions included interstitial
fibrosis of the kidney; polyarteritis of the mesenteric, pancreatic and other arteries; and
atrophy of the testes. Such lesions generally interfere with the health of the rats and with the development of
neoplasms. Dog receiving
endrin for two years had bone marrow
hyperplasia, lesions of the thyroid gland and lesions of the skeletal muscle, and
hyperplasias or
neoplasms of other organs. One female dog had an early
carcinoma of the thyroid gland. Mice ingesting
endrin developed increased incidences of
carcinomas of the liver and
sarcomas of the uterus.