Dercum's disease (adiposis dolorosa). Treatment of the severe pain with intravenous lidocaine.

Abstract

Dercum's disease (adiposis dolorosa) is associated with very painful subcutaneous fatty deposits normally localized to the lower extremities in which pain treatment is usually unsuccessful. Two patients with Dercum's disease have been treated repeatedly with intravenous lidocaine for several months each time resulting in immediate pain relief for 8 and 25 days respectively. Placebo infusions did not provide pain relief. Hereafter, the patients were treated with peroral mexiletine and again had complete pain relief. We conclude that intravenous lidocaine or peroral mexiletine may be an effective analgesic treatment in patients with Dercum's disease.

• Authors: Palle Petersen, Jens Kastrup
• Journal: Pain (Pain) Vol. 28 Issue 1 Pg. 77-80 (Jan 1987) ISSN: 0304-3959 [Print] United States
• PMID: 3822497 (Publication Type: Case Reports, Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Mexiletine
• Lidocaine

Topics

• Adiposis Dolorosa (complications, drug therapy)
• Adult
• Aged
• Aged, 80 and over
• Double-Blind Method
• Female
• Humans
• Injections, Intravenous
• Lidocaine (administration & dosage, therapeutic use)
• Male
• Mexiletine (administration & dosage, therapeutic use)
• Pain (drug therapy, etiology)