[Clinical evaluation of astromicin by intravenous drip infusion. Report I. Bacterial infections in the field of internal medicine].

Abstract

Intravenous drip infusion of a new aminoglycoside agent, astromicin (ASTM), was used against various infections in the field of internal medicine, and its clinical efficacy and safety were studied. Clinical effects were evaluated in 105 among 111 patients administered with ASTM. Almost all the patients were given 200 mg of ASTM twice a day by intravenous drip infusion for 60 minutes. Among 105 cases, clinical effects of ASTM were excellent in 15, good in 56, fair in 10 and poor in 24. The number of cases who were judged as excellent or good was 71, and the efficacy rate was 67.6%. Efficacy rates classified by diseases were as follows; 80% (4/5 cases) in sepsis, 55.6% (5/9 cases) in urinary tract infections, and 68.1 (62/91 cases) in respiratory tract infections (RTI). In 91 cases with RTI, clinical effects of ASTM were excellent in 14, good in 48, fair in 9 and poor in 20. The efficacy rates classified by diseases of RTI were 77.3% (34/44 cases) in pulmonary parenchyma infection and 59.6% (28/47 cases) in chronic RTI and others. As subjective and objective side effects, tinnitus and malaise were observed in 5 (4.5%) of 110 patients evaluated for side effects. But, either symptom was mild and disappeared after the end or withdrawal of administration. Slight elevations of S-GPT, BUN and others were observed in 7 cases (6.4%) as abnormal laboratory test values. Safety and efficacy of intravenous drip infusion of ASTM were confirmed.

• Authors: K Hara, A Saito, Y Shigeno, S Kohno, K Ishikawa, Y Kato, K Kikuchi, A Yamamoto, Y Hiraga, K Oizumi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 39 Issue 11 Pg. 2926-37 (Nov 1986) ISSN: 0368-2781 [Print] Japan
• PMID: 3820571 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aminoglycosides
• Anti-Bacterial Agents
• fortimicin A

Topics

• Adult
• Aged
• Aged, 80 and over
• Aminoglycosides (administration & dosage, therapeutic use)
• Anti-Bacterial Agents
• Bacterial Infections (drug therapy)
• Female
• Humans
• Infusions, Intravenous
• Male
• Middle Aged
• Respiratory Tract Infections (drug therapy)
• Sepsis (drug therapy)
• Urinary Tract Infections (drug therapy)