The authors study "in vitro" effects of sulfamethoxazol-trimethroprime (SMZ-
TMP) on 1 078 bacterial strains isolated from
urinary-tract infections during january 1974, the second trimester 1974 and january 1975. Study involves two parts : comparison between bacteriostatic activity of SMZ-
TMP,
ampicillin and
nalidixic acid; evaluation of bactericidal activity of
antibiotic associations including SMZ-
TMP. MIC study included all strains. On Gram- negative bacilli the bacteriostatic activity of SMZ-
TMP (74,6 percent of sensitive strains) was comparable with
nalidixic acid (79,6 percent of sensitive strains) and better than
ampicillin 31,4 percent of sensitive strains). On staphylococcus strains the bacteriostatic activity of SMZ-
TMP (84,6 percent of sensitive strains) is better than
ampicillin (36,4 percent of sensitive strains); on streptococcus strains the bacteriostatic activity of
ampicillin (71 percent of sensitive strains) is better than SMZ-
TMP (5l percent of sensitive strains). 473 associations including SMZ-
TMP were studied upon 44 strains of Gram- negative bacilli by bactericidal test. ("Cross disposition" method, derive from "
cellophane transfer method".