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Antibody to sialosyllactosaminylparagloboside in a patient with IgM paraproteinemia and polyradiculoneuropathy.

Abstract
Serum from a patient with IgM paraproteinemia and polyradiculoneuropathy, diagnosed as malignant lymphoma, reacted specifically with a ganglioside, sialosyllactosaminylparagloboside (SLPG), in human peripheral nerve but not with myelin-associated glycoprotein (MAG). This finding demonstrates the existence of anti-SLPG antibody in the patient's serum, suggesting that this antibody may play a role in the pathogenesis of neuropathy.
AuthorsN Miyatani, H Baba, S Sato, K Nakamura, T Yuasa, T Miyatake
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 14 Issue 2 Pg. 189-96 (Mar 1987) ISSN: 0165-5728 [Print] Netherlands
PMID3818942 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies
  • Gangliosides
  • Globosides
  • Glycosphingolipids
  • Immunoglobulin M
  • sialosyllactosaminylparagloboside
Topics
  • Aged
  • Antibodies (analysis)
  • Chromatography, Thin Layer
  • Enzyme-Linked Immunosorbent Assay
  • Gangliosides (metabolism)
  • Globosides (immunology)
  • Glycosphingolipids (immunology)
  • Histocytochemistry
  • Humans
  • Immunochemistry
  • Immunoglobulin M (analysis)
  • Male
  • Paraproteinemias (complications, immunology)
  • Polyradiculoneuropathy (complications, immunology)

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