Abstract |
End-plate and miniature end-plate potentials (EPP, MEPP) were recorded in the chick biventer cervicis muscle in vitro. The control frequency of discharge of MEPPs was 5.97 +/- 1.04 min-1, n = 10. Methohexitone (8.8 X 10(-5) M) did not affect the frequency of MEPP discharge, but tetraethylammonium ( TEA, 2.4-9.5 mM), reduced the frequency to 32.9 +/- 8.6% of the control. In the presence of neostigmine (3.3 X 10(-6) M) methohexitone (8.8 X 10(-5) M) reduced MEPP frequency to 38.7 +/- 5.4% of the control and TEA (2.4-9.5 mM) further reduced the frequency to 8.7 +/- 2.1% of the control. After a transient facilitation of the EPP, TEA (2.4-9.5 mM) in the presence of methohexitone (8.8 X 10(-5) M) and neostigmine (3.3 X 10(-6) M) markedly reduced EPP amplitude. The contractures which TEA produced in the presence of methohexitone were not due to an increase in the spontaneous release of vesicular ACh.
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Authors | R C Elliott |
Journal | General pharmacology
(Gen Pharmacol)
Vol. 17
Issue 6
Pg. 655-9
( 1986)
ISSN: 0306-3623 [Print] England |
PMID | 3817432
(Publication Type: Journal Article)
|
Chemical References |
- Tetraethylammonium Compounds
- Neostigmine
- Methohexital
|
Topics |
- Animals
- Chickens
- In Vitro Techniques
- Membrane Potentials
(drug effects)
- Methohexital
(pharmacology)
- Motor Endplate
(drug effects)
- Muscle Contraction
(drug effects)
- Muscle, Smooth
(drug effects)
- Neostigmine
(pharmacology)
- Neuromuscular Junction
(drug effects)
- Tetraethylammonium Compounds
(pharmacology)
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