[Mechanisms of the hemodynamic effects of nonachlazine in ischemic heart disease patients].

Abstract

During course therapy with nonachlazine of patients with ischemic heart disease, stable angina pectoris a negative inotropic effect of the drug in persons with eukinetic and in particular hyperkinetic type of hemodynamics was revealed. Enhancement of beta-adrenoblocking effect of nonachlazine with an increase of its daily dose was found. Nonachlazine effect on hemodynamic parameters was shown to be mediated through adrenoreactive structures.

• Authors: R M Zaslavskaia, R D Zolotaia, I Kh Olevskiĭ, S G Duda, F A Vilkovyskiĭ
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1986 Nov-Dec Vol. 49 Issue 6 Pg. 73-7 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: K voprosu o mekhanizmakh gemodinamicheskikh éffektov nonakhlazina u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.
• PMID: 3817152 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phenothiazines
• Nonachlazine

Topics

• Adrenal Glands (drug effects)
• Adult
• Aged
• Angina Pectoris (drug therapy, physiopathology)
• Coronary Disease (drug therapy, physiopathology)
• Drug Evaluation
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged
• Nonachlazine (pharmacology, therapeutic use)
• Phenothiazines (pharmacology)
• Physical Exertion (drug effects)
• Sympathetic Nervous System (drug effects)
• Time Factors