Effectiveness of pilocarpine in postradiation xerostomia.

Abstract

Pilocarpine and placebo tablets were administered for 90 day periods in a double-blind, sequential crossover trial to 12 patients with postradiation xerostomia. Salivary flow was measured by two techniques, symptomatic change and adverse side effects were also recorded. Nine of the 12 patients showed marked improvement by two or more criteria while taking pilocarpine. None of the 12 patients showed meaningful improvement while on placebo. Side effects were minimal and easily controlled. These results show that pilocarpine is effective in relieving the signs and symptoms of postradiation xerostomia.

• Authors: D Greenspan, T E Daniels
• Journal: Cancer (Cancer) Vol. 59 Issue 6 Pg. 1123-5 (Mar 15 1987) ISSN: 0008-543X [Print] United States
• PMID: 3815287 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Pilocarpine

Topics

• Carcinoma (radiotherapy)
• Head and Neck Neoplasms (radiotherapy)
• Humans
• Parotid Gland (metabolism)
• Pilocarpine (therapeutic use)
• Radiotherapy (adverse effects)
• Salivation (drug effects)
• Xerostomia (drug therapy, etiology)