Age-related changes in striatal dopamine activity following nigral muscimol infusions.

Abstract	Microinfusions of muscimol into the substantia nigra pars reticulata produced marked increases in striatal dopamine (DA) utilization without affecting striatal DA concentration in adult rats. In contrast, muscimol increased striatal DA concentration and decreased DA utilization in 16-day-old rat pups. The striatal norepinephrine concentration was not altered in either group. Since previous studies have shown that similar infusions of muscimol are anticonvulsant in adults and proconvulsant in rat pups, our results suggest that the nigrostriatal pathway may play an important role in mediating the nigral effects on seizures.
Authors	S L Moshé, E F Sperber, J N Wurpel, N S Sharpless
Journal	Brain research (Brain Res) Vol. 428 Issue 1 Pg. 129-32 (Jan 1987) ISSN: 0006-8993 [Print] Netherlands
PMID	3815107 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Muscimol Dopamine
Topics	Aging Animals Behavior, Animal (drug effects) Corpus Striatum (cytology, metabolism) Dopamine (metabolism) Injections Muscimol (pharmacology) Neurons (metabolism) Rats Rats, Inbred Strains Substantia Nigra (physiology)

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