[Effect of vitamin A deficiency on the macromolecular permeability of small intestine mucosa in the adult rat].

Abstract

Adult rats with experimental vitamin A deficiency and control animals were intraperitoneally injected with chicken ovalbumin (OA) solution and the entrance of native OA into the blood was assessed 3 hours later by competitive radioimmunoassay. The OA amounts circulating in the blood of control animals averaged (0.39 +/- 0.06) X 10(-4)% of the consumed dose, while in the experimental group it averaged (1.33 +/- 0.42) 10(-4)%. Electron microscopy, using colloid lanthanum hydroxide, has shown vitamin A deficiency to give rise to an abrupt reduction in glycocalix layer, as compared to the control, without increasing erythrocyte membrane permeability for tracer particles. It is concluded that vitamin A deficiency leads to a considerable damage of small intestinal permeability for protein macromolecules.

• Authors: I V Gmoshinskiĭ, S I Khvylia, I Ia Kon'
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 103 Issue 2 Pg. 161-3 (Feb 1987) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie nedostatochnosti vitamina A na pronitsaemost' slizistoĭ obolochki tonkoĭ kishki vzroslykh krys dlia makromolekul.
• PMID: 3814795 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Colloids
• Macromolecular Substances
• lanthanum hydroxide
• Lanthanum
• Ovalbumin

Topics

• Animals
• Cell Membrane Permeability
• Colloids
• Intestinal Mucosa (metabolism, ultrastructure)
• Intestine, Small (metabolism, ultrastructure)
• Lanthanum (metabolism)
• Macromolecular Substances
• Microscopy, Electron
• Ovalbumin (metabolism)
• Rats
• Vitamin A Deficiency (metabolism, pathology)