Abstract |
The toxicity of daily subcutaneously applied 500 mg/kg N-methylformamide (NMF) during a period of 8 days in female CD-mice was ameliorated when 100 mg/kg sodium ascorbate, 60 mg/kg menadione bisulfite or 80 mg/kg pyridoxal hydrochloride were applied simultaneously. The comparison of the daily s.c. application of 360 mg/kg NMF with the intermittent s.c. injection of 720 mg/kg NMF with an interval of 48 h in P 388 leukemia showed that the daily application of NMF induced an increase of life span of 82% whereas the intermittent schedule effected a 142% increase of life span. The simultaneous combination of 360 mg/kg NMF with 60 mg/kg sodium ascorbate applied daily caused a 133% increase of life span and the simultaneous combination of 360 mg/kg NMF with 30 mg/kg menadione sodium bisulfite lead to a 126% increase of life span. The combined daily s.c. application of 360 mg/kg NMF with 30 mg/kg pyridoxal hydrochloride induced only a minimal difference compared to the daily application of 360 mg/kg NMF alone. The combination of 720 mg/kg NMF with 120 mg/kg sodium ascorbate applied in intervals of 48 h showed a 164% increase of life span. In advanced M 5076 sarcoma the daily s.c. application of 360 mg/kg NMF effected a 82% increase of life span and the combination of 360 mg/kg NMF with 60 mg/kg sodium ascorbate effected a 135% increase of life span.
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Authors | H Osswald, R Herrmann, M Youssef |
Journal | Toxicology
(Toxicology)
Vol. 43
Issue 2
Pg. 183-91
(Feb 1987)
ISSN: 0300-483X [Print] Ireland |
PMID | 3810660
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Formamides
- Vitamin K
- Pyridoxal
- Vitamin K 3
- Ascorbic Acid
- methylformamide
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Ascorbic Acid
(pharmacology)
- Drug Synergism
- Female
- Formamides
(therapeutic use)
- Leukemia P388
(drug therapy)
- Life Expectancy
- Mice
- Pyridoxal
(pharmacology)
- Sarcoma, Experimental
(drug therapy)
- Vitamin K
(analogs & derivatives, pharmacology)
- Vitamin K 3
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