Abstract |
With the purpose to define the specific activity of substances acting on the cerebral circulation and metabolism, (-) eburnamonine and cinnarizine were compared in a double-blind study carried out in a group of 106 elderly patients suffering from established chronic brain ischemia. The photoscintigraphic and rheoencephalographic studies carried out on some of the patients showed that only (-) eburnamonine had a clear-cut activity on brain circulation. (-) Eburnamonine also showed an activity on kidney circulation. With regard to the clinical picture, a statistical evaluation of the results obtained showed that both drugs improve psychic disturbances and the overall clinical picture. Cinnarizine appears to influence, to a slightly greater extent, some neurological symptoms, while (-) eburnamonine exerts a significantly better action on daily living activities and general psychic efficiency.
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Authors | M Passeri |
Journal | European neurology
(Eur Neurol)
Vol. 17 Suppl 1
Pg. 150-8
( 1978)
ISSN: 0014-3022 [Print] Switzerland |
PMID | 381005
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Piperazines
- Placebos
- Vasodilator Agents
- Vinca Alkaloids
- Cinnarizine
|
Topics |
- Aged
- Brain
(metabolism)
- Brain Ischemia
(drug therapy)
- Cerebrovascular Circulation
(drug effects)
- Chronic Disease
- Cinnarizine
(therapeutic use)
- Clinical Trials as Topic
- Double-Blind Method
- Drug Evaluation
- Female
- Humans
- Male
- Piperazines
(therapeutic use)
- Placebos
- Vasodilator Agents
(therapeutic use)
- Vinca Alkaloids
(therapeutic use)
|