Acute sulfolane exposure produces temperature-independent and dependent changes in visual evoked potentials.

Abstract

Sulfolane (tetrahydrothiophene-1, 1-dioxide) is a commercially important solvent. This report describes the consequences of acute exposure to sulfolane upon the visual system, as measured using flash evoked potentials (FEPs) and pattern reversal evoked potentials (PREPs). A single injection of either 1/2 or 1/4, but not 1/8 the IP LD50 (1600 mg/kg) produced significant changes in both FEPs and PREPs which were apparent within 1 hour and lasted longer than 6 hours. Amplitudes of FEP peaks to the first of a pair of stimuli were generally increased compared to control, an effect which was not temperature-dependent. In addition, sulfolane produced an ambient temperature- and dose-dependent hypothermia. Sulfolane increased latencies of FEP and PREP peaks, but attenuating hypothermia eliminated the effect of sulfolane on latencies.

• Authors: R S Dyer, W K Boyes, B E Hetzler
• Journal: Neurobehavioral toxicology and teratology (Neurobehav Toxicol Teratol) 1986 Nov-Dec Vol. 8 Issue 6 Pg. 687-93 ISSN: 0275-1380 [Print] United States
• PMID: 3808184 (Publication Type: Journal Article)

Chemical References

• Thiophenes
• sulfolane

Topics

• Animals
• Dose-Response Relationship, Drug
• Evoked Potentials, Visual (drug effects)
• Hypothermia (chemically induced)
• Male
• Photic Stimulation
• Rats
• Rats, Inbred Strains
• Reaction Time
• Thiophenes (toxicity)