Abstract |
Forty-two couples in an infertility clinic were examined for genital infection with Mycoplasma hominis or Ureaplasma urealyticum (T strains). In 21 couples one or other partner was found to be infected; no chlamydiae, trichomonads, or gonococci were isolated from any of these couples. All patients were then included in a double-blind crossover doxycycline/placebo study lasting 8 months. Pregnancy was achieved in one of the 21 couples who were free of infection. Of the 21 couples who were infected, one achieved a pregnancy while still infected, and 19 lost their infection on doxycycline, of whom four achieved a pregnancy. These four pregnancies all occurred among the 10 couples who received doxycycline first. One further pregnancy occurred after the trial was over. Since 5 of the 7 pregnancies occurred in the first 4 months of the trial, they were probably due to the psychological effect of treatment rather than the effect of the drug on infection.
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Authors | R A Hinton, L M Egdell, B E Andrews, S K Clarke, S J Richmond |
Journal | British journal of obstetrics and gynaecology
(Br J Obstet Gynaecol)
Vol. 86
Issue 5
Pg. 379-83
(May 1979)
ISSN: 0306-5456 [Print] England |
PMID | 380631
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Clinical Trials as Topic
- Double-Blind Method
- Doxycycline
(therapeutic use)
- Female
- Genital Diseases, Female
(drug therapy)
- Genital Diseases, Male
(drug therapy)
- Humans
- Infertility
(drug therapy, etiology)
- Male
- Mycoplasma Infections
(complications, drug therapy)
- Pregnancy
- Ureaplasma
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