Brain-stem tumors in childhood: a prospective randomized trial of irradiation with and without adjuvant CCNU, VCR, and prednisone. A report of the Childrens Cancer Study Group.

Abstract

Seventy-four children with a brain-stem tumor diagnosed between 1977 and 1980 were entered into a prospective study in which exploration and assessment for resection were optional, radiation treatment using standard methods was required, and randomization occurred with regard to the use of adjuvant chemotherapy (1-(2-chloroethyl)-1-nitrosourea, vincristine, and prednisone) or no further treatment. The overall 5-year survival rate was 20% and was not improved by the adjuvant chemotherapy program. An increased risk of infection was associated with the adjuvant therapy.

• Authors: R D Jenkin, C Boesel, I Ertel, A Evans, R Hittle, J Ortega, R Sposto, W Wara, C Wilson, J Anderson
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 66 Issue 2 Pg. 227-33 (Feb 1987) ISSN: 0022-3085 [Print] United States
• PMID: 3806204 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Vincristine
• Lomustine
• Prednisone

Topics

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Brain Neoplasms (therapy)
• Brain Stem (diagnostic imaging)
• Child
• Child, Preschool
• Combined Modality Therapy
• Female
• Humans
• Lomustine (administration & dosage)
• Male
• Medulla Oblongata (diagnostic imaging)
• Neoplasm Recurrence, Local (drug therapy)
• Pons (diagnostic imaging)
• Prednisone (administration & dosage)
• Prospective Studies
• Radiography
• Random Allocation
• Vincristine (administration & dosage)