Chronic
heart failure (CHF) is a key part of cardiovascular continuum. Under the guidance of the theory of vessel-collateral doctrine, the present study proposes therapeutic benefits of Qili
Qiangxin (QLQX) capsules, an innovative Chinese medicine, on chronic
heart failure. The studies show that multiple targets of the
drug on CHF, including enhancing myocardial systole, promoting urine excretion, inhibiting excessive activation of the neuroendocrine system, preventing
ventricular remodeling by inhibiting inflammatory response, myocardial
fibrosis, apoptosis and autophagy, enhancing myocardial energy metabolism, promoting angiogenesis, and improving endothelial function. Investigation on the effects and mechanism of the
drug is beneficial to the treatment of chronic
heart failure (CHF) through multiple targets and/or signaling pathways. Meanwhile, it provides new insights to further understand other refractory diseases in the cardiovascular continuum, and it also has an important theoretical and practical significance in enhancing prevention and
therapeutic effect of
traditional Chinese medicine for these diseases.