Enhancing effect of 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran on diethylnitrosamine hepatocarcinogenesis in rats.

Abstract

Enhancement of diethylnitrosamine(DENA)-induced hepatic tumor production in rats was observed by sequential exposure to 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) or 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF). This effect was more evident in the group of rats treated with 2,3,4,7,8-PenCDF (80 micrograms/rat), in which approximately 43% of this compound administered was accumulated in the liver at 8 weeks after the last treatment.

• Authors: M Nishizumi, Y Masuda
• Journal: Cancer letters (Cancer Lett) Vol. 33 Issue 3 Pg. 333-9 (Dec 1986) ISSN: 0304-3835 [Print] Ireland
• PMID: 3802062 (Publication Type: Journal Article)

Chemical References

• Benzofurans
• Polymers
• polychlorodibenzofuran
• Diethylnitrosamine
• 1,2,3,4,7,8-hexachlorodibenzofuran
• 2,3,4,7,8-pentachlorodibenzofuran

Topics

• Animals
• Benzofurans (metabolism, toxicity)
• Body Weight (drug effects)
• Diethylnitrosamine
• Liver Neoplasms, Experimental (chemically induced, pathology)
• Male
• Polymers
• Rats
• Rats, Inbred Strains
• Thymus Gland (drug effects)