[Participation of kynurenine and its derivatives in disorders of the cardiac rhythm].

Abstract

The influence of tryptophan derivatives: L-kynurenine, 3-hydroxy-DL-kynurenine, kynurenic, xanthurenic, 3-hydroxy-anthranilic and quinolinic acids has been investigated in isolated frog heart. It has been established that L-kynurenine, 3-hydroxy-DL-kynurenine, xanthurenic acid and quinolinic acid at a concentration of 10(-6)-10(-3) mol/l initiate bradycardia. In some cases xanthurenic and quinolinic acids cause a one-minute cardiac arrest in early diastole. 3-hydroxy-anthranilic acid at a concentration of 10(-5) and 5 X 10(-5) mol/l produces premature beats and attacks of tachycardia. In the experiments, using 10(-6)-10(-3) mol/l of kynurenic acid, no impairment of the cardiac rhythm was observed in the isolated frog heart.

• Authors: V K Rudzit, G O Silenietse, Ia B Irgenson
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 102 Issue 12 Pg. 719-21 (Dec 1986) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Uchastie kinurenina i ego proizvodnykh v narusheniiakh serdechnogo ritma.
• PMID: 3801625 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Kynurenine

Topics

• Animals
• Arrhythmias, Cardiac (etiology)
• Dose-Response Relationship, Drug
• Heart Rate (drug effects)
• In Vitro Techniques
• Kynurenine (analogs & derivatives, pharmacology, physiology)
• Ranidae