[Hemodynamic mechanisms of the hypotensive action of the new calcium antagonist foridon in acute hypertension in rabbits. A comparison with nifedipine].
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| Abstract |
The radioactive microsphere technique was used to study hemodynamic mechanisms of action of 2 calcium antagonists--foridon and nifedipine in conscious rabbits with acute hypertension evoked by immobilization. Microspheres were injected before and 5 min after bolus i.v. injection of equihypotensive (10% blood pressure drop) doses of nifedipine (30 mcg/kg) and foridon (50 mcg/kg). Nifedipine in most cases decreased cardiac index by 7% without significant changes in regional hemodynamic. After foridon injection total peripheral resistance decreased by 19% (P less than 0.05) and cardiac index increased by 18%. There were increase in blood flow: in the heart by 34% (P less than 0.05), in the skeletal muscle by 41% (P less than 0.05) and in testes by 12% (P less than 0.05). The results show that in acute stress-induced hypertension these dihydropyridine-derivatives have different hemodynamic mechanisms of action: nifedipine preferentially depress myocardial contractility, whereas foridon dilates blood vessels.
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| Authors | O S Medvedev, E V Glukhovtsev, S F Dugin |
| Journal | Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR (Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR) Vol. 9 Issue 2 Pg. 44-9 ( 1986) ISSN: 0201-7369 [Print] Russia (Federation) |
| Vernacular Title | Gemodinamicheskie mekhanizmy gipotenzivnogo deĭstviia novogo antagonista kal'tsiia foridona pri ostroĭ gipertonii u krolikov. Sravenie s nifedipinom. |
| PMID | 3801131 (Publication Type: Comparative Study, English Abstract, Journal Article) |
| Chemical References |
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