Calcification of Bruch's membrane in angioid streaks with homozygous sickle cell disease.

Abstract

Histochemical and light and electron microscopic studies of two eyes of a patient with homozygous sickle cell disease and angioid streaks demonstrated heavy calcification and breaks in Bruch's membrane. We were unable to demonstrate iron deposition by histochemical techniques or transmission electron microscopy. These studies suggest that calcification rather than iron deposition is the major factor leading to brittleness of Bruch's membrane in patients with hemolytic anemia and angioid streaks.

• Authors: L M Jampol, R Acheson, R C Eagle Jr, G Serjeant, R O'Grady
• Journal: Archives of ophthalmology (Chicago, Ill. : 1960) (Arch Ophthalmol) Vol. 105 Issue 1 Pg. 93-8 (Jan 1987) ISSN: 0003-9950 [Print] United States
• PMID: 3800752 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Topics

• Anemia, Sickle Cell (complications)
• Calcinosis (complications, pathology)
• Choroid (ultrastructure)
• Homozygote
• Humans
• Male
• Microscopy, Electron
• Middle Aged
• Sickle Cell Trait (complications, genetics, pathology)
• Uveal Diseases (complications, pathology)