Xylotubercidin against herpes simplex virus type 2 in mice.

Abstract

Of a series of newly synthesized derivatives of the pyrrolo[2,3-d]pyrimidine nucleosides tubercidin, toyocamycin, and sangivamycin, the xylosyl analog of tubercidin, xylotubercidin, exhibited the greatest potency and selectivity against herpes simplex virus type 2 (HSV-2) in vitro. At dosage regimens that were not toxic for the host, xylotubercidin proved efficacious in various HSV-2 animal model infections. When applied topically at 0.25, 0.5, or 1% in dimethyl sulfoxide or when administered systemically (intraperitoneally) at 12.5 or 25 mg/kg per day, xylotubercidin suppressed the development of herpetic skin lesions and the paralysis and mortality associated therewith in hairless mice inoculated intracutaneously with HSV-2. In this model, acyclovir was effective only if administered topically at 5 or 10% in dimethyl sulfoxide. When administered intraperitoneally over a dosage range of 10 to 50 mg/kg per day, xylotubercidin achieved a significant reduction in the mortality rate of mice infected intraperitoneally with HSV-2. Under the same conditions, acyclovir did not offer any protection even when administered at doses up to 250 mg/kg per day. Xylotubercidin thus appears to have considerable potential for both topical and systemic treatment of HSV-2 infections.

• Authors: E De Clercq, M J Robins
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 30 Issue 5 Pg. 719-24 (Nov 1986) ISSN: 0066-4804 [Print] United States
• PMID: 3800347 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Ribonucleosides
• xylotubercidin
• Tubercidin
• Acyclovir

Topics

• Acyclovir (therapeutic use)
• Animals
• Antiviral Agents (pharmacology, therapeutic use)
• Disease Models, Animal
• Herpes Simplex (drug therapy)
• Mice
• Mice, Inbred Strains
• Ribonucleosides (therapeutic use)
• Tubercidin (analogs & derivatives, pharmacology, therapeutic use)