Chronic skin
wounds represent a prominent etiological factor in the occurrence of non-traumatic foot
amputations on a global scale and pose a substantial threat to the patient's well-being and mortality in the absence of effective treatment strategies. There exists a subset of patients that exhibit an insufficient response to different treatment options, comprising
antibiotics, dressings, gauze bandages,
debridement, rehabilitation,
collagen patch, and
vacuum-assisted closure. In this patient group, distinct treatment strategies emerge before surgery and
amputation.
Ozone therapy is one of them.
Ozone exhibits a wide variety of effects such as antimicrobial, anti-inflammatory,
antioxidant, and trophic. Its trophic effect is mediated by disinfection, stimulation of granulation tissue, acceleration of the angiogenesis process, and detoxification mechanisms. In this article, we presented the beneficial effect of
ozone therapy in a case of chronic
skin ulcer associated with
livedoid vasculopathy. In this context, we aimed to discuss the role of
ozone therapy in the management of chronic
skin ulcers. Finally, we focused on
ozone therapy as a promising method in inflammatory
rheumatic diseases.