Abstract |
To determine whether occult eosinophil degranulation occurs in lymphomas, the authors performed immunohistologic and cytochemical studies on cryostat sections from 25 consecutive lymph node biopsies. A glucose-oxidase immunohistochemical technique was employed with a murine monoclonal antibody specific for human eosinophil peroxidase (EPO). In 7 cases of Hodgkin's disease, 3 cases of T- immunoblastic sarcoma, and 1 case of small cleaved follicular center cell lymphoma with sclerosis, there was extensive and striking extracellular deposition of EPO in a granular and fibrillar pattern within the connective tissue. Similar degranulation of eosinophils was not observed in any of the benign lymph node specimens or other B-cell lymphomas. It is concluded that eosinophils extensively degranulate and release EPO in some types of lymphoma.
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Authors | M K Samoszuk, B N Nathwani, R J Lukes |
Journal | The American journal of pathology
(Am J Pathol)
Vol. 125
Issue 3
Pg. 426-9
(Dec 1986)
ISSN: 0002-9440 [Print] United States |
PMID | 3799814
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Monoclonal
- Eosinophil Peroxidase
- Peroxidases
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Topics |
- Antibodies, Monoclonal
- Eosinophil Peroxidase
- Eosinophils
(enzymology, pathology)
- Hodgkin Disease
(enzymology, pathology)
- Humans
- Lymph Nodes
(cytology)
- Lymphoma, Non-Hodgkin
(enzymology)
- Peroxidases
(immunology, metabolism)
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