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Extensive deposition of eosinophil peroxidase in Hodgkin's and non-Hodgkin's lymphomas.

Abstract
To determine whether occult eosinophil degranulation occurs in lymphomas, the authors performed immunohistologic and cytochemical studies on cryostat sections from 25 consecutive lymph node biopsies. A glucose-oxidase immunohistochemical technique was employed with a murine monoclonal antibody specific for human eosinophil peroxidase (EPO). In 7 cases of Hodgkin's disease, 3 cases of T-immunoblastic sarcoma, and 1 case of small cleaved follicular center cell lymphoma with sclerosis, there was extensive and striking extracellular deposition of EPO in a granular and fibrillar pattern within the connective tissue. Similar degranulation of eosinophils was not observed in any of the benign lymph node specimens or other B-cell lymphomas. It is concluded that eosinophils extensively degranulate and release EPO in some types of lymphoma.
AuthorsM K Samoszuk, B N Nathwani, R J Lukes
JournalThe American journal of pathology (Am J Pathol) Vol. 125 Issue 3 Pg. 426-9 (Dec 1986) ISSN: 0002-9440 [Print] United States
PMID3799814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Monoclonal
  • Eosinophil Peroxidase
  • Peroxidases
Topics
  • Antibodies, Monoclonal
  • Eosinophil Peroxidase
  • Eosinophils (enzymology, pathology)
  • Hodgkin Disease (enzymology, pathology)
  • Humans
  • Lymph Nodes (cytology)
  • Lymphoma, Non-Hodgkin (enzymology)
  • Peroxidases (immunology, metabolism)

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