| Abstract | Post-operative recurrence of hydatid disease occurs in approximately 10% of patients. The role of pre- or post-spillage chemotherapy with albendazole (10 mg/kg) was investigated in a gerbil model. All animals received approximately 5000 protoscoleces of ovine Echinococcus granulosus by intraperitoneal injection. Pre-spillage albendazole therapy did not protect against the development of cysts whilst a significant reduction in numbers of peritoneal cysts was seen in gerbils treated with albendazole 10 mg/kg for one week after inoculation. Two weeks therapy was no more effective. A very short course of albendazole treatment immediately following intraperitoneal 'spillage' of protoscoleces in a gerbil significantly reduced the number of cysts which developed. This finding may well be of clinical value. |
| Authors | D L Morris, J B Chinnery, J D Hardcastle |
| Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene
(Trans R Soc Trop Med Hyg)
Vol. 80
Issue 3
Pg. 481-4
( 1986)
ISSN: 0035-9203 ENGLAND |
| PMID | 3798546
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anthelmintics
- Benzimidazoles
- Albendazole
|
| Topics |
- Albendazole
- Animals
- Anthelmintics
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Disease Models, Animal
- Echinococcosis
(prevention & control)
- Echinococcosis, Hepatic
(pathology)
- Female
- Gerbillinae
- Liver
(pathology)
- Male
|
