Abstract |
The conventional dose of recombinant human thrombopoietin (rhTPO) in the treatment of immune thrombocytopenia ( ITP) is 300 U/kg per day, but the clinical reaction rate is not satisfactory. Accordingly, we explored the efficacy and safety of increasing rhTPO dose in the treatment of ITP. A retrospective study was conducted to collect the clinical data of 105 ITP patients who were divided into two groups, a low-dose group (15 000 U/day) and a high-dose group (30 000 U/day) according to the dose of rhTPO. The total effective rate of the low-dose group and the high-dose group was 31/44 (70.45%) vs. 56/61 (91.80%) (P = .049), and the average time of using rhTPO in the high-dose group was shorter than that in the low-dose group (7 days vs. 10 days, P = .001). On the 7th and 14th day of treatment, the efficacy of the high-dose group was better than that of the low-dose group [45/61 (73.77%) vs. 17/44 (38.64%), P < .001; 55/60 (91.67%) vs. 30/44 (68.18%), P < .05)]. The incidence of treatment related adverse events in the low-dose group and the high-dose group was 6/44 (13.64%) vs. 6/61 (9.84%) (P > .05), which were mild and transient in nature. In our study, high-dose rhTPO had good efficacy and high safety in the treatment of ITP with the efficacy better than low-dose rhTPO especially at day 7.
|
Authors | Xiuli Wang, Hui Bi, Lin Liu, Yuebo Liu, Liefen Yin, Jin Yao, Jingxing Yu, Wei Tao, Yueping Wei, Yu Li, Lingmei Yin, Hongli Mu, Yadong Du, Zeping Zhou |
Journal | Platelets
(Platelets)
Vol. 34
Issue 1
Pg. 2271568
(Dec 2023)
ISSN: 1369-1635 [Electronic] England |
PMID | 37941414
(Publication Type: Journal Article)
|
Chemical References |
- Thrombopoietin
- Recombinant Proteins
|
Topics |
- Humans
- Purpura, Thrombocytopenic, Idiopathic
(drug therapy)
- Thrombopoietin
(adverse effects)
- Platelet Count
- Retrospective Studies
- Thrombocytopenia
(drug therapy)
- Recombinant Proteins
(therapeutic use)
|