Rapid tumor regression and induction of tumor-regressing activity in serum by various immune-modulating agents.

Abstract

A rapid decrease in the number of tumor cells from S180 tumors was caused by several antitumor polysaccharides including the beta (1-3)glucans lentinan and TAK-N and a mannoglucan MGA, but not by those lacking antitumor activity. MGA was demonstrated to induce potent tumor-regressing activity in the serum of tumor-bearing mice similar to that reported previously to be induced after an injection of CM-TAK, a carboxymethylated beta (1-3)glucan. It is probable that the induction of rapid regression of established tumors is a phenomenon common to antitumor polysaccharides and some microbiological products and that the tumor-regressing factor in the serum underlies a common mechanism.

• Authors: H Baba, T Kunimoto, K Nitta, K Sato, S Hashimoto, M Kohno, Y Kita, H Ogawa
• Journal: International journal of immunopharmacology (Int J Immunopharmacol) Vol. 8 Issue 6 Pg. 569-72 ( 1986) ISSN: 0192-0561 [Print] England
• PMID: 3793324 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polysaccharides

Topics

• Animals
• Immunotherapy
• Mice
• Mice, Inbred ICR
• Polysaccharides (therapeutic use)
• Sarcoma 180 (blood, immunology, therapy)