Lung tumor induction in strain A mice with benzotrichloride.

Abstract

Benzotrichloride (BTC) is used in the synthesis of benzoyl chloride and benzoyl peroxide. Epidemiological data suggest that BTC is a human lung carcinogen. In the present study, BTC was evaluated for its ability to induce lung adenomas in strain A/J mice. Four groups of 15 male and 15 female A/J mice were injected i.p. with either tricaprylin or BTC in tricaprylin three times a week for 8 weeks. BTC groups received doses totaling 1440 mg/kg, 719 mg/kg or 287 mg/kg. The mean number of lung tumors per mouse was 127 87 +/- 5.81, 43 +/- 2.44, and 17.73 +/- 1.09 in the groups treated with either 1440 mg/kg, 719 mg/kg, or 287 mg/kg, respectively. Tricaprylin-vehicle controls had a mean number of 0.46 +/- 0.15 lung tumors per mouse. Therefore, BTC produced a significant (P less than 0.001) and dose-related increase in the lung tumor response when compared to tricaprylin controls and is a potent carcinogen in the strain A mouse lung tumor bioassay.

• Authors: G D Stoner, M You, M A Morgan, M J Superczynski
• Journal: Cancer letters (Cancer Lett) Vol. 33 Issue 2 Pg. 167-73 (Nov 1986) ISSN: 0304-3835 [Print] Ireland
• PMID: 3791187 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Toluene
• Urethane
• benzotrichloride

Topics

• Animals
• Dose-Response Relationship, Drug
• Female
• Lung Neoplasms (chemically induced)
• Male
• Mice
• Mice, Inbred Strains
• Toluene (analogs & derivatives, toxicity)
• Urethane (toxicity)