Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid.

Abstract

Mycobacterial sulfatides (sulfolipids) in admixture with endotoxin had tumor regressive activity comparable to trehalose-6,6'-dimycolate (TDM) and endotoxin in guinea pigs, but unlike TDM were neither toxic nor granulomagenic and had no antitumor activity in mice. The increased endotoxin lethality in mice pretreated with BCG was not observed in mice pretreated with sulfolipids or TDM instead of BCG.

• Authors: E Yarkoni, M B Goren, H J Rapp
• Journal: Infection and immunity (Infect Immun) Vol. 24 Issue 2 Pg. 357-62 (May 1979) ISSN: 0019-9567 [Print] United States
• PMID: 378852 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Bacterial Vaccines
• Emulsions
• Endotoxins
• Sulfoglycosphingolipids

Topics

• Animals
• Bacterial Vaccines (therapeutic use, toxicity)
• Emulsions
• Endotoxins (therapeutic use)
• Immunotherapy
• Liver Neoplasms, Experimental (therapy)
• Male
• Mice
• Mycobacterium (immunology)
• Neoplasm Transplantation
• Salmonella typhimurium (immunology)
• Sulfoglycosphingolipids (therapeutic use)