CTNNB1 somatic mutations drive Wnt pathway activation in a case of incidental intranodal palisaded myofibroblastoma.

Abstract

Intranodal palisaded myofibroblastoma (IPM) is a rare stroma-derived spindle-cell neoplasm of the lymph node with myofibroblastic differentiation and CTNNB1 (β-catenin gene) somatic mutations. We present a case of IPM found incidentally in the staging of lung adenocarcinoma. We describe the major histopathological and phenotypic features, including a palisaded bland spindle cell proliferation with myofibroblastic differentiation and Wnt pathway activation by immunohistochemistry, including β-catenin expression. Production of osteoid-like collagen directly from tumor cells was observed. We confirmed p.Gly34Arg CTNNB1 mutation by direct sequencing. We also reviewed the literature for similar cases.

• Authors: Germán Moreno de Juan, Santiago Montes Moreno
• Journal: Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia (Rev Esp Patol) 2023 Oct-Dec Vol. 56 Issue 4 Pg. 279-283 ISSN: 1988-561X [Electronic] Spain
• PMID: 37879826 (Publication Type: Case Reports)
• Copyright: Copyright © 2023 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.

Chemical References

• beta Catenin
• CTNNB1 protein, human

Topics

• Humans
• beta Catenin (genetics, metabolism)
• Wnt Signaling Pathway (genetics)
• Lymph Nodes (pathology)
• Neoplasms, Muscle Tissue (genetics, metabolism, pathology)
• Mutation