[Corneal contact time of artificial tear solutions].

Abstract

In 30 subjects without ophthalmological disease the corneal contact time of a new artificial polyacrylic-based tear gel (Vidisic, produced by Dr. Mann, Berlin) was compared with a well-known artificial polyvinyl alcohol-based tear solution. The Vidisic concentration remained in the corneal tear film 7 times longer than the substance it was compared with. In a second study including 7 normal subjects and 5 patients with keratoconjunctivitis sicca, the influence of Vidisic on break-up time (BUT) and the Schirmer test was demonstrated. It was found that tear secretion improved for 2-4 hours (Schirmer test) and the stability of the tear film (BUT) improved for about 6 hours with Vidisic. These results suggest that application of Vidisic four times a day is sufficient for efficatious therapy even in cases of severe keratoconjunctivitis sicca.

• Authors: R Marquardt, T Christ
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 189 Issue 3 Pg. 254-7 (Sep 1986) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Untersuchungen zur Verweildauer von Tränenersatzmitteln.
• PMID: 3784417 (Publication Type: English Abstract, Journal Article)

Chemical References

• Acrylates
• Ophthalmic Solutions
• Surface-Active Agents
• Wetting Agents
• vidisic
• Polyvinyl Alcohol

Topics

• Acrylates (metabolism)
• Cornea (metabolism)
• Female
• Humans
• Keratoconjunctivitis Sicca (metabolism, therapy)
• Male
• Middle Aged
• Ophthalmic Solutions
• Polyvinyl Alcohol (metabolism)
• Surface-Active Agents (metabolism)
• Tears (metabolism)
• Wetting Agents (metabolism, therapeutic use)