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Phase II evaluation of ftorafur in previously untreated colorectal cancer: a Southwest Oncology Group Study.

Abstract
Eighty-four previously untreated patients with metastatic adenocarcinoma of the large intestine received intravenous ftorafur at a dosage of 2.25 g/m2/day for 5 consecutive days. Courses were repeated every three weeks. Regressions were noted in 9 of 84 treated patients (11%). Median survival for all patients was 32 weeks. Responders survived only 5 weeks longer than nonresponders; 36 vs. 31 weeks. Central nervous system toxicity was a limiting factor occurring in one-third of patients. Ftorafur in a daily X5 schedule appears not to make a significant contribution to the management of disseminated colorectal cancer.
AuthorsT Buroker, F Padilla, C Groppe, G Guy, J Quagliana, J McCracken, V K Vaitkevicius, B Hoogstraten, L Heilbrun
JournalCancer (Cancer) Vol. 44 Issue 1 Pg. 48-51 (Jul 1979) ISSN: 0008-543X [Print] UNITED STATES
PMID378365 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Tegafur
  • Fluorouracil
Topics
  • Adenocarcinoma (drug therapy)
  • Adult
  • Aged
  • Central Nervous System (drug effects)
  • Colonic Neoplasms (drug therapy)
  • Drug Evaluation
  • Female
  • Fluorouracil (analogs & derivatives)
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Rectal Neoplasms (drug therapy)
  • Remission, Spontaneous
  • Tegafur (adverse effects, pharmacology)
  • Time Factors

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