Isoflurane: its use to induce hypotension in neurosurgical patients.

Abstract

The use of isoflurane to induce arterial hypotension was studied in 40 adults undergoing neurosurgery. In 70% of patients, isoflurane, up to 2.0% (inspired), decreased mean arterial pressure (MAP) to the desired level for surgery; for the remainder, a higher concentration (3.0-4.0%) was required. Tachycardia, which could be slowed by labetalol, occurred in 13 patients (32%); the incidence was significantly higher in those who had not received an opiate either as premedication or intra-operatively. No post-operative complications attributable to hypotension were seen. It is concluded that isoflurane is a safe and effective agent for the induction of hypotension in neurosurgical operations.

• Authors: T V Campkin, R M Flinn
• Journal: European journal of anaesthesiology (Eur J Anaesthesiol) Vol. 3 Issue 5 Pg. 395-401 (Sep 1986) ISSN: 0265-0215 [Print] England
• PMID: 3780696 (Publication Type: Journal Article)

Chemical References

• Isoflurane

Topics

• Adolescent
• Adult
• Aged
• Anesthesia
• Blood Pressure (drug effects)
• Craniotomy
• Electrocardiography
• Female
• Heart Rate (drug effects)
• Humans
• Hypophysectomy
• Hypotension, Controlled
• Isoflurane
• Male
• Middle Aged
• Neurosurgical Procedures