Abstract |
Anti- ulcer properties of 2-(3,4-dimethoxyphenyl)-5-methylthiazolidine-4-one (KM-1146) were investigated on various experimental ulcers in comparison with cimetidine. While both KM-1146 and cimetidine at the same dose were comparative on the preventive effects of Shay- and stress- ulcers, KM-1146 was more effective against different necrotizing agents such as 0.2N NaOH and 99.5% ethanol at non-antisecretory dose. KM-1146 50 mg significantly accelerated the healing of acetic acid-induced ulcers while cimetidine 200 mg had no effect. KM-1146 increased rat gastric mucosal blood flow as measured by hydrogen gas clearance and prevented a decrease of gastric mucus gel thickness induced by water immersion restraint stress. These studies indicate that KM-1146 exerts cytoprotective action even in anti-secretory dose in addition to a significant anti- ulcer action which is comparable to cimetidine.
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Authors | Y Matsuo, H Kuwayama, H Itoh, A Seki, S Fukuda, T Kawasaki, T Hotta, Y Ohsaka, K Komatsu |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 36
Issue 8
Pg. 1236-40
(Aug 1986)
ISSN: 0004-4172 [Print] Germany |
PMID | 3778561
(Publication Type: Journal Article)
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Chemical References |
- Acetates
- Anti-Ulcer Agents
- Thiazoles
- Ethanol
- Cimetidine
- KM 1146
- Indomethacin
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Topics |
- Acetates
- Animals
- Anti-Ulcer Agents
(pharmacology)
- Cell Survival
(drug effects)
- Cimetidine
(pharmacology)
- Ethanol
- Gastric Mucosa
(blood supply)
- Indomethacin
- Male
- Rats
- Rats, Inbred Strains
- Regional Blood Flow
(drug effects)
- Stomach Ulcer
(chemically induced)
- Thiazoles
(pharmacology)
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