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Gastric anti-ulcer and cytoprotective properties of 2-(3,4-dimethoxyphenyl)-5-methyl-thiazolidine-4-one in rat experimental ulcers.

Abstract
Anti-ulcer properties of 2-(3,4-dimethoxyphenyl)-5-methylthiazolidine-4-one (KM-1146) were investigated on various experimental ulcers in comparison with cimetidine. While both KM-1146 and cimetidine at the same dose were comparative on the preventive effects of Shay- and stress-ulcers, KM-1146 was more effective against different necrotizing agents such as 0.2N NaOH and 99.5% ethanol at non-antisecretory dose. KM-1146 50 mg significantly accelerated the healing of acetic acid-induced ulcers while cimetidine 200 mg had no effect. KM-1146 increased rat gastric mucosal blood flow as measured by hydrogen gas clearance and prevented a decrease of gastric mucus gel thickness induced by water immersion restraint stress. These studies indicate that KM-1146 exerts cytoprotective action even in anti-secretory dose in addition to a significant anti-ulcer action which is comparable to cimetidine.
AuthorsY Matsuo, H Kuwayama, H Itoh, A Seki, S Fukuda, T Kawasaki, T Hotta, Y Ohsaka, K Komatsu
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 36 Issue 8 Pg. 1236-40 (Aug 1986) ISSN: 0004-4172 [Print] Germany
PMID3778561 (Publication Type: Journal Article)
Chemical References
  • Acetates
  • Anti-Ulcer Agents
  • Thiazoles
  • Ethanol
  • Cimetidine
  • KM 1146
  • Indomethacin
Topics
  • Acetates
  • Animals
  • Anti-Ulcer Agents (pharmacology)
  • Cell Survival (drug effects)
  • Cimetidine (pharmacology)
  • Ethanol
  • Gastric Mucosa (blood supply)
  • Indomethacin
  • Male
  • Rats
  • Rats, Inbred Strains
  • Regional Blood Flow (drug effects)
  • Stomach Ulcer (chemically induced)
  • Thiazoles (pharmacology)

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