Metoclopramide suppositories in the treatment of diabetic gastroparesis.

Abstract

Gastroparesis diabeticorum is a common complication that develops in patients with diabetes mellitus. Although the pathogenesis remains unclear, the clinical symptoms of nausea, vomiting, and gastric dilatation frequently respond to metoclopramide hydrochloride, an agent that stimulates gastric emptying in addition to acting centrally as an antiemetic. Occasionally, patients are encountered whose severe gastroparesis is unresponsive to oral metoclopramide and who require intravenous therapy or drainage procedures (eg, pyloroplasty or gastrojejunostomy). Rectal administration of metoclopramide successfully controlled the clinical symptoms of gastroparesis diabeticorum in an outpatient after failure of oral dosing, thus avoiding the need for intravenous therapy. Gastric emptying studies and serum metoclopramide levels following a 25-mg rectal dose of metoclopramide hydrochloride verified the efficacy of therapy.

• Authors: B C Trapnell, L E Mavko, L M Birskovich, J M Falko
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 146 Issue 11 Pg. 2278-9 (Nov 1986) ISSN: 0003-9926 [Print] United States
• PMID: 3778059 (Publication Type: Case Reports, Journal Article)

Chemical References

• Suppositories
• Metoclopramide

Topics

• Adult
• Diabetes Mellitus, Type 1 (complications)
• Female
• Gastric Emptying (drug effects)
• Humans
• Metoclopramide (administration & dosage, blood)
• Stomach Diseases (blood, drug therapy, etiology)
• Suppositories