What role will ensifentrine play in the future treatment of chronic obstructive pulmonary disease patients? Implications from recent clinical trials.

Abstract

Data from the phase III ENHANCE clinical trials provide compelling evidence that ensifentrine, an inhaled 'bifunctional' dual phosphodiesterase 3/4 inhibitor, can provide additional benefit to existing treatments in patients with chronic obstructive pulmonary disease and represents a 'first-in-class' drug having bifunctional bronchodilator and anti-inflammatory activity in a single molecule. Ensifentrine, generally well tolerated, can provide additional bronchodilation when added to muscarinic receptor antagonists or β2-agonists and reduce the exacerbation risk. This information allows us to consider better the possible inclusion of ensifentrine in the future treatment of chronic obstructive pulmonary disease. However, there is less information on whether it provides additional benefit when added to inhaled corticosteroid or 'triple therapy' and, therefore, when this drug is best utilized in clinical practice.

• Authors: Mario Cazzola, Clive Page, Luigino Calzetta, Dave Singh, Paola Rogliani, Maria Gabriella Matera
• Journal: Immunotherapy (Immunotherapy) Vol. 15 Issue 18 Pg. 1511-1519 (Dec 2023) ISSN: 1750-7448 [Electronic] England
• PMID: 37779474 (Publication Type: Journal Article, Review)

Chemical References

• ensifentrine
• Isoquinolines
• Pyrimidinones
• Bronchodilator Agents

Topics

• Humans
• Pulmonary Disease, Chronic Obstructive (drug therapy)
• Isoquinolines (pharmacology, therapeutic use)
• Pyrimidinones (therapeutic use)
• Bronchodilator Agents (therapeutic use)
• Administration, Inhalation