UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.

Abstract

UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, we classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describe its involvement in key canonical cancer signaling pathways, and identify methods to inhibit UGDH, its substrates, and its downstream products. As such, we position UGDH as an enzyme to be exploited as a potential prognostication marker in oncology and a therapeutic target in cancer biology.

• Authors: Meghan J Price, Annee D Nguyen, Jovita K Byemerwa, Jasmine Flowers, César D Baëta, C Rory Goodwin
• Journal: Oncotarget (Oncotarget) Vol. 14 Pg. 843-857 (09 28 2023) ISSN: 1949-2553 [Electronic] United States
• PMID: 37769033 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Uridine Diphosphate Glucose Dehydrogenase
• Uridine Diphosphate Glucose
• Glucose
• Glucose Dehydrogenases

Topics

• Humans
• Uridine Diphosphate Glucose Dehydrogenase (genetics, chemistry)
• Uridine Diphosphate Glucose
• Neoplasms (genetics)
• Medical Oncology
• Glucose
• Biology
• Glucose Dehydrogenases