Opiate-antagonist reversal of neurological deficits--experimental and clinical studies.

Abstract

The proximal left M1 and the common trunk of A2 were clipped in 12 adult dogs. Naloxone was injected after placing the clips onto 6 dogs. Neither the systemic blood pressure nor the local cerebral blood flow were influenced by naloxone. In another group of 6 dogs with chronic right hemiplegia, naloxone proved passably effective in improving the hemiplegia. Eight patients with neurological deficits of various etiologies were administered levallorphan. The improvement in motor performance and/or elevation of mental activity was observed more or less in all but 2 of the patients. It was considered that the effect of opiate antagonists is based partially on the facilitation of synaptic transmission exaggerated by the arousal response.

• Authors: S Namba, S Nishigaki, N Fujiwara, T Wani, Y Namba, T Masaoka
• Journal: The Japanese journal of psychiatry and neurology (Jpn J Psychiatry Neurol) Vol. 40 Issue 1 Pg. 61-79 (Mar 1986) ISSN: 0912-2036 [Print] Japan
• PMID: 3773354 (Publication Type: Case Reports, Journal Article)

Chemical References

• Narcotic Antagonists
• Levallorphan
• Naloxone

Topics

• Adult
• Aged
• Animals
• Blood Flow Velocity
• Brain Ischemia (complications, drug therapy)
• Cats
• Cerebrovascular Circulation (drug effects)
• Chick Embryo
• Disease Models, Animal
• Dogs
• Female
• Humans
• Injections, Intravenous
• Levallorphan (therapeutic use)
• Male
• Middle Aged
• Naloxone (therapeutic use)
• Narcotic Antagonists (therapeutic use)
• Nervous System Diseases (drug therapy, etiology)
• Tomography, X-Ray Computed