The effect of conductive aligned fibers in an injectable hydrogel on nerve tissue regeneration.

Abstract

Injectable hydrogels are a promising treatment option for nervous system injuries due to the difficulty to replace lost cells and nervous factors but research on injectable conductive hydrogels is limited and these scaffolds have poor electromechanical properties. This study developed a chitosan/beta-glycerophosphate/salt hydrogel and added conductive aligned nanofibers (polycaprolactone/gelatin/single-wall carbon nanotube (SWCNT)) for the first time and inspired by natural nerve tissue to improve their biochemical and biophysical properties. The results showed that the degradation rate of hydrogels is proportional to the regrowth of axons and these hydrogels' mechanical (hydrogels without nanofibers or SWCNTs and hydrogels containing these additions have the same Young's modulus as the brain and spinal cord or peripheral nerves, respectively) and electrical properties, and the interconnective structure of the scaffolds have the ability to support cells.

• Authors: Yasaman Mozhdehbakhsh Mofrad, Amir Shamloo
• Journal: International journal of pharmaceutics (Int J Pharm) Vol. 645 Pg. 123419 (Oct 15 2023) ISSN: 1873-3476 [Electronic] Netherlands
• PMID: 37717716 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Elsevier B.V. All rights reserved.