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Direct cardiac actions of phenylephrine when used in assessment of baroreflex function in the rat.

Abstract
In pentobarbitone-anaesthetised wistar rats, the baroreflex bradycardia in response to the vasopressor agent phenylephrine was converted to a tachycardia by propranolol. In pithed wistar rats, phenylephrine produced a marked tachycardia which was mediated largely by beta-adrenoreceptors since propranolol markedly antagonised the response. A component of the tachycardia was mediated by alpha 1-adrenoreceptors since the tachycardia to phenylephrine in the presence of propranolol was antagonised by prazosin and mimicked by the alpha 1-adrenoreceptor agonist amidephrine. It is concluded that phenylephrine is not a useful agent for assessment of baroreflex function in the rat due to its marked cardiac stimulant actions.
AuthorsR Sawyer, J R Docherty
JournalJournal of autonomic pharmacology (J Auton Pharmacol) Vol. 6 Issue 3 Pg. 215-7 (Sep 1986) ISSN: 0144-1795 [Print] England
PMID3771593 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ethanolamines
  • Phenylephrine
  • Atropine
  • amidephrine
  • Propranolol
Topics
  • Animals
  • Atropine (pharmacology)
  • Ethanolamines (pharmacology)
  • Heart (drug effects)
  • Heart Rate (drug effects)
  • Male
  • Phenylephrine (pharmacology)
  • Pressoreceptors (drug effects)
  • Propranolol (pharmacology)
  • Rats
  • Rats, Inbred Strains
  • Reflex (drug effects)

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