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Immunomodulation by tamoxifen and pergolide.

Abstract
Treatment of rats with tamoxifen citrate or pergolide mesylate was as effective in inhibiting antibody formation and contact sensitivity skin reactions as was hypophysectomy. The immunocompetence of tamoxifen citrate- and pergolide mesylate-suppressed animals could be fully restored by additional treatment with prolactin or growth hormone.
AuthorsE Nagy, I Berczi
JournalImmunopharmacology (Immunopharmacology) Vol. 12 Issue 2 Pg. 145-53 (Oct 1986) ISSN: 0162-3109 [Print] Netherlands
PMID3771192 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dopamine Antagonists
  • Estrogen Antagonists
  • Estrogens
  • Tamoxifen
  • Pergolide
  • Prolactin
  • Growth Hormone
Topics
  • Animals
  • Antibody Formation (drug effects)
  • Depression, Chemical
  • Dermatitis, Contact (immunology)
  • Dopamine Antagonists
  • Estrogen Antagonists (pharmacology)
  • Estrogens (physiology)
  • Female
  • Growth Hormone (pharmacology)
  • Immunity, Cellular (drug effects)
  • Immunosuppression Therapy
  • Pergolide (antagonists & inhibitors, pharmacology)
  • Prolactin (pharmacology)
  • Rats
  • Rats, Inbred F344
  • Tamoxifen (antagonists & inhibitors, pharmacology)

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