| Abstract | A hypotensive effect of corinfar and its effect on the indices of the central and peripheral hemodynamics were studied in 50 patients with stage II hypertension. In 3 weeks BP was lowered at the expense of a considerable decrease in the total peripheral vascular resistance (TPVR) (by 29.6%) and regional vascular resistance (by 48%). It was accompanied by an increase in the peripheral blood flow (by 61%), a reflex activation of the sympathetic-adrenal system with an increase in heart rate and cardiac output (by 22%, p less than 0.001). An index of vein distensibility remained unchanged. The addition of propranolol removed signs of the sympathetic stimulation of the cardiac activity, improved vasodilatator tolerance, enhanced a hypotensive effect of corinfar causing a transient increase in TPVR and tension of the resistive vessels only. By the end of the 4th month of therapy these indices significantly decreased. A prolonged combined therapy with corinfar and propranolol resulted in a significant decrease in the resistance of resistive vessels in maximum vasodilatation characterizing the regression of arteriole structural changes. Besides there was a decrease in the wall thickness (p less than 0.01) and left ventricular myocardial mass (by 7.88 +/- 2.66 g, p less than 0.05) that was interpreted as a tendency to a decrease in a degree of hypertrophy of the left ventricle. The efficacy of corinfar therapy was higher in the patients with hypertension with a high initial tension of the peripheral vessels. |
| Authors | I K Shkhvatsabaia, E V Erina, T N Prokopova, Kh E Charyev, E G D'iakonova |
| Journal | Terapevticheskiĭ arkhiv
(Ter Arkh)
Vol. 58
Issue 6
Pg. 122-7
( 1986)
ISSN: 0040-3660 USSR |
| Vernacular Title | Lechenie gipertonicheskoĭ bolezni antagonistom kal'tsiia korinfarom i ego sochetaniem s obzidanom. |
| PMID | 3764704
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Calcium Channel Blockers
- Nifedipine
- Propranolol
|
| Topics |
- Adult
- Calcium Channel Blockers
(adverse effects, therapeutic use)
- Chronic Disease
- Drug Evaluation
- Drug Therapy, Combination
- Hemodynamics
(drug effects)
- Humans
- Hypertension
(drug therapy, physiopathology)
- Male
- Middle Aged
- Nifedipine
(therapeutic use)
- Propranolol
(therapeutic use)
- Time Factors
|
