Significance of elevated urinary N-acetyl-beta-D-glucosaminidase activity in chronic cadmium poisoning.

Abstract

N-Acetyl-beta-D-glucosaminidase (NAG) activity and beta 2-microglobulin (beta 2-m) concentration were measured in the urine of inhabitants of a cadmium-polluted area (Cd), including patients with, or suspected, "itai-itai" disease and control subjects. Urinary NAG activity increased with increasing beta 2-m concentration up to about 100 U/g creatinine; above this value the NAG activity did not increase with increasing beta 2-m concentration. Urinary NAG activity thus represents another useful indicator of renal tubular damage caused by Cd poisoning since the mechanisms for the excretion of NAG and beta 2-m into urine are thought to be different.

• Authors: K Nogawa, Y Yamada, T Kido, R Honda, M Ishizaki, I Tsuritani, E Kobayashi
• Journal: The Science of the total environment (Sci Total Environ) Vol. 53 Issue 3 Pg. 173-8 (Sep 1986) ISSN: 0048-9697 [Print] Netherlands
• PMID: 3764409 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Hexosaminidases
• Acetylglucosaminidase

Topics

• Acetylglucosaminidase (urine)
• Cadmium Poisoning (diagnosis, enzymology)
• Clinical Enzyme Tests
• Hexosaminidases (urine)
• Humans
• Reference Values