Studies on the efficacy of diethyxime as an antidote against organophosphorus intoxication in rats.

Abstract

Diethyxime, a non-quaternary cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index, cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked antidotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphate (DFP) poisoning was not observed with this reactivator.

• Authors: S N Dube, A K Ghosh, K Jeevarathinam, D Kumar, S Das Gupta, B P Pant, B S Batra, D K Jaiswal
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 41 Issue 3 Pg. 267-71 (Jul 1986) ISSN: 0021-5198 [Print] Japan
• PMID: 3761745 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antidotes
• Cholinesterase Reactivators
• Oximes
• Isoflurophate
• diethyxime
• Atropine
• Dichlorvos
• Cholinesterases

Topics

• Animals
• Antidotes
• Atropine (pharmacology)
• Bradycardia (chemically induced)
• Cholinesterase Reactivators (therapeutic use)
• Cholinesterases (blood)
• Dichlorvos (antagonists & inhibitors)
• Isoflurophate (antagonists & inhibitors)
• Neuromuscular Diseases (chemically induced)
• Oximes (therapeutic use)
• Rats