| Abstract | Sera from 20 patients with systemic lupus erythematosus (SLE) and active central nervous system (CNS) dysfunction were examined by indirect immunofluorescence for antibodies to neuronal membrane determinants. Warm-reactive IgG antibodies were demonstrable in 82% (9/11) of patients with clinical evidence for seizures or diffuse CNS disease, but these antibodies generally were absent in non-CNS SLE sera or when focal neurologic deficit or psychosis was the primary CNS manifestation. Cold-reactive antibodies of the IgM class were equally prevalent in patients with or without CNS disease and appeared to be more directly correlated with extra-CNS systemic illness. Absorption experiments with lymphocytes, brain homogenate, and various other tissues suggested a predominant brain-specificity for IgG antibodies and partial lymphocyte cross-reactivity for IgM antibodies. Interpretations of this special association between IgG anti-brain antibodies and diffuse CNS dysfunction in SLE are discussed. |
| Authors | H A Wilson, J B Winfield, R G Lahita, D Koffler |
| Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 22
Issue 5
Pg. 458-62
(May 1979)
ISSN: 0004-3591 UNITED STATES |
| PMID | 375939
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
- Autoantibodies
- Immunoglobulin G
- Indicators and Reagents
|
| Topics |
- Autoantibodies
(analysis)
- Brain
(immunology)
- Cell Line
- Central Nervous System Diseases
(immunology)
- Cytotoxicity Tests, Immunologic
- Delirium, Dementia, Amnestic, Cognitive Disorders
(etiology)
- Fluorescent Antibody Technique
- Humans
- Immunoglobulin G
(analysis)
- Indicators and Reagents
- Lupus Erythematosus, Systemic
(immunology)
- Neuroblastoma
(immunology)
- Seizures
(etiology)
|
