Ocular penetration and efficacy of chloroethyldeoxyuridine against herpetic keratouveitis.

Abstract

Topical administration of 0.1% or 1% chloroethyldeoxyuridine eyedrops caused a significant reduction in the severity of experimental herpes simplex iritis and stromal keratitis in rabbits. The healing effect caused by chloroethyldeoxyuridine was comparable to that obtained with 0.1% and 0.5% bromovinylde-oxyuridine eyedrops. The drug levels achieved in the anterior chamber fluid following topical application of 1% eyedrops of [2-14C]CEDU, a radiolabelled analogue of chloroethyldeoxyuridine, were well above the minimum concentration (0.1 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. The beneficial effects of chloroethyldeoxyuridine on stomal keratitis and iritis appear consistent with its efficient penetration through the cornea.

• Authors: P C Maudgal, E De Clercq, R Bernaerts, M Dieltiens, M Breemersch, L Van Eeckhoutte
• Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 27 Issue 10 Pg. 1453-8 (Oct 1986) ISSN: 0146-0404 [Print] United States
• PMID: 3759363 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Ophthalmic Solutions
• brivudine
• 5-(2-chloroethyl)-2'-deoxyuridine
• Bromodeoxyuridine
• Deoxyuridine

Topics

• Animals
• Anterior Chamber (metabolism)
• Antiviral Agents (metabolism, therapeutic use)
• Bromodeoxyuridine (analogs & derivatives, therapeutic use)
• Deoxyuridine (analogs & derivatives, metabolism, therapeutic use)
• Iritis (drug therapy, etiology)
• Keratitis, Dendritic (drug therapy)
• Ophthalmic Solutions
• Rabbits