Management of Acquired Factor X Deficiency Caused by In Vitro Non-neutralizing Anti-factor X Autoantibodies with Pre-emptive Corticosteroid Therapy.

Abstract

Coagulation factor X (FX) deficiency causes severe hemorrhagic symptoms. We herein report a 90-year-old man with hemorrhagic symptoms and prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT). Cross-mixing tests showed a factor deficiency pattern, but administration of plasma products was not effective. Acquired coagulation factor deficiency was suspected, and immunosuppressive therapy was started. After the intervention, his hemorrhagic symptoms improved. A decrease in FX activity was later confirmed, and anti-FX autoantibody was retrospectively detected by an enzyme-linked immunosorbent assay. Immediate intervention is important for patients suspected of having acquired coagulation factor deficiency.

• Authors: Akio Onishi, Yuji Shimura, Takahisa Nakamura, Masayoshi Souri, Tsukasa Osaki, Shinsuke Mizutani, Taku Tsukamoto, Tsutomu Kobayashi, Akitada Ichinose, Junya Kuroda
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 62 Issue 16 Pg. 2401-2406 ( 2023) ISSN: 1349-7235 [Electronic] Japan
• PMID: 37587057 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Autoantibodies
• Blood Coagulation Factors

Topics

• Male
• Humans
• Aged, 80 and over
• Factor X Deficiency (drug therapy)
• Retrospective Studies
• Adrenal Cortex Hormones
• Autoantibodies
• Blood Coagulation Factors